Science

Mozart is developing CD8 Treg modulators for the treatment of autoimmune and inflammatory diseases.

The Regulatory CD8 T Cell Network

Regulatory CD8 T cells play a key role in regulating self-tolerance by selectively probing for and eliminating auto-reactive and pathogenic CD4 T cells and possibly other immune cells. However, in autoimmune disease, this network fails to control the activation and expansion of pathogenic CD4 T cells, resulting in a downstream cascade of inflammatory events that ultimately can lead to tissue destruction.

Downstream Inflammation

downstream cascade of inflammatory illustration

Our Approach

We are targeting the regulatory CD8 T cell network to counteract early events in the inflammatory cascade. Therapeutic modulation of this network is designed to restore the functions of CD8 Tregs to suppress and eliminate pathogenic immune cells, providing durable control of autoimmune and inflammatory diseases.

CD8 Treg Modulators

CD8 Treg Modulators illustration

CD8 Treg modulators are disease modifying therapeutic molecules that selectively target the regulatory CD8 T cell network to counteract early events in the autoimmune inflammatory cascade. CD8 Treg Modulators are designed to restore the intrinsic functions of regulatory CD8 T cells to suppress and eliminate pathogenic immune cells, providing durable control of autoimmune and other inflammatory diseases.